There is still much to understand about the science and genetics of hair loss.  Scientists pretty much agree that what causes hair loss in males revolves around DHT, dihydrotestosterone. DHT is produced when the enzyme (a chemical which changes other chemicals in the body) 5 alpha reductase reacts  with your male hormone, testosterone.   In susceptible men, the hair root becomes sensitive (like becoming allergic) to its own DHT and reacts by shutting off the blood flow to the root.  The hair root is pretty much committing suicide at this stage. So the DHT is starving the hair roots of blood which in effect is preventing them from getting food and oxygen.   The hair follicle weakens, the hair it produces  gets… read more

In a number of previous blog entries and also extensively in the forums, it has been reported that a cocktail of hair loss products often works better than one single hair loss product, therefore attacking the chemical and physiological causes of hair loss from a number of angles. For example, ProFusion Shampoo and Conditioner can be used with Propecia (Finasteride) and Regaine (Minoxidil). How does Finasteride Work? This involves a lot of biological terms but we have tried to explain these where possible. Finasteride inhibits an enzyme in your body called Type II 5α-reductase. This enzyme converts testosterone into Dihydrotestosterone (DHT). Two distinct isoenzymes (or isozymes) are found in humans: Type I and II. Isozymes have a slightly different chemical… read more

Spironolactone was originally marketed by Searle as a Aldactone as a potassium sparing diuretic, that is it makes you pass more urine but doesn’t deplete your body of potassium. Diuretics are used to control blood pressure among other uses. The use of Spironolactone as a hair loss treatment is a fairly new phenomenum. It has a powerful antiandrogenic effect, in simple terms it works to reduce the male hormone testosterone by decreasing production and also blocking the effect of androgens at a cellular level. Spironolactone is a competitive inhibitor of dihydrotestosterone (DHT) receptor binding. The drug competes with testosterone for the androgen receptors on each cell so less testosterone can bind to it. It has also been suggested that the… read more